Florian I. Schmidt Lab

SARS-CoV-2 Neutralizing Nanobodies

Project details

In a joint project with the Core Facility Nanobodies at the University of Bonn, we have generated SARS-CoV-2 neutralizing nanobodies to study mechanistic aspects of virus fusion and to develop novel antiviral biologics. While we continue to investigate basic research aspects of SARS-CoV-2 infection and fusion with nanobodies, the clinical development of antiviral SARS-CoV-2 nanobodies is pursued by the spin-out company DiosCURE Therapeutics SE (Link: https://www.dioscure.com/company) of the University of Bonn.

Project-related publications

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI.

Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12.

Project-related funding

Medical Faculty

Medical Faculty, University of Bonn

Project-related scientists

BTC Core Facility - Nanobodies
Florian Schmidt Lab
Florian Schmidt Lab
BTC Core Facility - Nanobodies
Florian Schmidt Lab
BTC Core Facility - Nanobodies

Other Projects