Bernardo Franklin Lab Publications

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.

Platelets Fuel the Inflammasome Activation of Innate Immune Cells

Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS.

Cell Rep. 2020 May 12;31(6):107615. doi: 10.1016/j.celrep.2020.107615.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Bertheloot D, Latz E, Franklin BS.

Cell Mol Immunol. 2021 May;18(5):1106-1121. doi: 10.1038/s41423-020-00630-3. Epub 2021 Mar 30.

Regulation of Innate Immune Responses by Platelets

Ribeiro LS, Migliari Branco L, Franklin BS.

Front Immunol. 2019 Jun 11;10:1320. doi: 10.3389/fimmu.2019.01320. eCollection 2019.

The intra- and extracellular functions of ASC specks

Franklin BS, Latz E, Schmidt FI.

Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611.

Crystal Formation in Inflammation

Franklin BS, Mangan MS, Latz E.

Annu Rev Immunol. 2016 May 20;34:173-202. doi: 10.1146/annurev-immunol-041015-055539. Epub 2016 Jan 11.

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.

Platelets supply p38 MAPK signaling that licenses pro-inflammatory cytokine responses of human monocytes

Ibrahim Hawwari, Nathalia Sofia Rosero Reyes, Lucas S. Ribeiro, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Bernardo S. Franklin

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Bertheloot D, Latz E, Franklin BS.

Cell Mol Immunol. 2021 May;18(5):1106-1121. doi: 10.1038/s41423-020-00630-3. Epub 2021 Mar 30.

The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia

Santos MLS, Coimbra RS, Sousa TN, Guimarães LFF, Gomes MS, Amaral LR, Pereira DB, Fontes CJF, Hawwari I, Franklin BS, Carvalho LH.

Front Cell Infect Microbiol. 2021 Mar 15;11:631333. doi: 10.3389/fcimb.2021.631333. eCollection 2021.

The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia

Santos, M.L.S., Coimbra, R.S., Sousa, T.N., Guimaraes, L.F.F., Gomes, M.S., Amaral, L.R., Pereira, D.B., Fontes, C.J.F., Hawwari, I., Franklin, B.S., Carvalho L.H.

Platelets Fuel the Inflammasome Activation of Innate Immune Cells

Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS.

Cell Rep. 2020 May 12;31(6):107615. doi: 10.1016/j.celrep.2020.107615.

Molecular basis of carrageenan-induced cytokines production in macrophages

Lopes AH, Silva RL, Fonseca MD, Gomes FI, Maganin AG, Ribeiro LS, Marques LMM, Cunha FQ, Alves-Filho JC, Zamboni DS, Lopes NP, Franklin BS, Gombault A, Ramalho FS, Quesniaux VFJ, Couillin I, Ryffel B, Cunha TM.

Cell Commun Signal. 2020 Sep 7;18(1):141. doi: 10.1186/s12964-020-00621-x.

Regulation of Innate Immune Responses by Platelets

Ribeiro LS, Migliari Branco L, Franklin BS.

Front Immunol. 2019 Jun 11;10:1320. doi: 10.3389/fimmu.2019.01320. eCollection 2019.

Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages

Rodríguez-Alcázar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenmüller W, Latz E, Franklin BS.

J Immunol. 2019 Jan 15;202(2):550-558. doi: 10.4049/jimmunol.1800107. Epub 2018 Dec 17.

The intra- and extracellular functions of ASC specks

Franklin BS, Latz E, Schmidt FI.

Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611.

Detection of ASC Speck Formation by Flow Cytometry and Chemical Cross-linking

Hoss F, Rolfes V, Davanso MR, Braga TT, Franklin BS.

Methods Mol Biol. 2018;1714:149-165. doi: 10.1007/978-1-4939-7519-8_10.

PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy

Rolfes V, Idel C, Pries R, Plötze-Martin K, Habermann J, Gemoll T, Bohnet S, Latz E, Ribbat-Idel J, Franklin BS, Wollenberg B.

Oncotarget. 2018 Jun 8;9(44):27460-27470. doi: 10.18632/oncotarget.25446. eCollection 2018 Jun 8.

Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients

Ahmad F, Mishra N, Ahrenstorf G, Franklin BS, Latz E, Schmidt RE, Bossaller L.

AIDS. 2018 Jan 28;32(3):299-307. doi: 10.1097/QAD.0000000000001693.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E.

J Exp Med. 2017 Jun 5;214(6):1725-1736. doi: 10.1084/jem.20160933. Epub 2017 May 2.

Soluble Uric Acid Activates the NLRP3 Inflammasome

Braga TT, Forni MF, Correa-Costa M, Ramos RN, Barbuto JA, Branco P, Castoldi A, Hiyane MI, Davanso MR, Latz E, Franklin BS, Kowaltowski AJ, Camara NO.

Sci Rep. 2017 Jan 13;7:39884. doi: 10.1038/srep39884.

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.

Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. Epub 2017 Sep 21.

Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6

Jansen F, Stumpf T, Proebsting S, Franklin BS, Wenzel D, Pfeifer P, Flender A, Schmitz T, Yang X, Fleischmann BK, Nickenig G, Werner N.

J Mol Cell Cardiol. 2017 Mar;104:43-52. doi: 10.1016/j.yjmcc.2016.12.005. Epub 2017 Jan 28.

Crystal Formation in Inflammation

Franklin BS, Mangan MS, Latz E.

Annu Rev Immunol. 2016 May 20;34:173-202. doi: 10.1146/annurev-immunol-041015-055539. Epub 2016 Jan 11.

Statins improve NASH via inhibition of RhoA and Ras

Schierwagen R, Maybüchen L, Hittatiya K, Klein S, Uschner FE, Braga TT, Franklin BS, Nickenig G, Strassburg CP, Plat J, Sauerbruch T, Latz E, Lütjohann D, Zimmer S, Trebicka J.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G724-G733. doi: 10.1152/ajpgi.00063.2016. Epub 2016 Sep 15.

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.

Kidney Int. 2016 Sep;90(3):525-39. doi: 10.1016/j.kint.2016.03.035. Epub 2016 Jun 2.

Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence

Beilharz M, De Nardo D, Latz E, Franklin BS.

Methods Mol Biol. 2016;1417:145-58. doi: 10.1007/978-1-4939-3566-6_9.

Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus

Jansen F, Wang H, Przybilla D, Franklin BS, Dolf A, Pfeifer P, Schmitz T, Flender A, Endl E, Nickenig G, Werner N.

Cardiovasc Diabetol. 2016 Mar 22;15:49. doi: 10.1186/s12933-016-0367-8.

The inflammasomes and autoinflammatory syndromes

Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E.

Annu Rev Pathol. 2015;10:395-424. doi: 10.1146/annurev-pathol-012414-040431. Epub 2014 Nov 19.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection

Ataide MA, Andrade WA, Zamboni DS, Wang D, Souza Mdo C, Franklin BS, Elian S, Martins FS, Pereira D, Reed G, Fitzgerald KA, Golenbock DT, Gazzinelli RT.

PLoS Pathog. 2014 Jan;10(1):e1003885. doi: 10.1371/journal.ppat.1003885. Epub 2014 Jan 16.

MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease

Jansen F, Yang X, Proebsting S, Hoelscher M, Przybilla D, Baumann K, Schmitz T, Dolf A, Endl E, Franklin BS, Sinning JM, Vasa-Nicotera M, Nickenig G, Werner N.

J Am Heart Assoc. 2014 Oct 27;3(6):e001249. doi: 10.1161/JAHA.114.001249.

High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation

Jansen F, Yang X, Franklin BS, Hoelscher M, Schmitz T, Bedorf J, Nickenig G, Werner N.

Cardiovasc Res. 2013 Apr 1;98(1):94-106. doi: 10.1093/cvr/cvt013. Epub 2013 Jan 22.

Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles

Jansen F, Yang X, Hoelscher M, Cattelan A, Schmitz T, Proebsting S, Wenzel D, Vosen S, Franklin BS, Fleischmann BK, Nickenig G, Werner N.

Circulation. 2013 Oct 29;128(18):2026-38. doi: 10.1161/CIRCULATIONAHA.113.001720. Epub 2013 Sep 6.

For gut's sake: NLRC4 inflammasomes distinguish friend from foe

Franklin BS, Latz E.

Nat Immunol. 2012 Apr 18;13(5):429-31. doi: 10.1038/ni.2289.

Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis

Jansen F, Yang X, Hoyer FF, Paul K, Heiermann N, Becher MU, Abu Hussein N, Kebschull M, Bedorf J, Franklin BS, Latz E, Nickenig G, Werner N.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1925-35. doi: 10.1161/ATVBAHA.112.253229. Epub 2012 Jun 14.

Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W, Ataíde MA, de Oliveira RB, Golenbock DT, Gazzinelli RT.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. doi: 10.1073/pnas.1015406108. Epub 2011 Feb 8.

Plasma circulating nucleic acids levels increase according to the morbidity of Plasmodium vivax malaria

Franklin BS, Vitorino BL, Coelho HC, Menezes-Neto A, Santos ML, Campos FM, Brito CF, Fontes CJ, Lacerda MV, Carvalho LH.

PLoS One. 2011;6(5):e19842. doi: 10.1371/journal.pone.0019842. Epub 2011 May 17.

Augmented plasma microparticles during acute Plasmodium vivax infection

Campos FM, Franklin BS, Teixeira-Carvalho A, Filho AL, de Paula SC, Fontes CJ, Brito CF, Carvalho LH.

Malar J. 2010 Nov 16;9:327. doi: 10.1186/1475-2875-9-327.

Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function

Franklin BS, Parroche P, Ataíde MA, Lauw F, Ropert C, de Oliveira RB, Pereira D, Tada MS, Nogueira P, da Silva LH, Bjorkbacka H, Golenbock DT, Gazzinelli RT.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5789-94. doi: 10.1073/pnas.0809742106. Epub 2009 Mar 18.

Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria

Ropert C, Franklin BS, Gazzinelli RT.

Semin Immunopathol. 2008 Feb;30(1):41-51. doi: 10.1007/s00281-007-0103-2. Epub 2007 Dec 11.

MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria

Franklin BS, Rodrigues SO, Antonelli LR, Oliveira RV, Goncalves AM, Sales-Junior PA, Valente EP, Alvarez-Leite JI, Ropert C, Golenbock DT, Gazzinelli RT.

Microbes Infect. 2007 Jun;9(7):881-90. doi: 10.1016/j.micinf.2007.03.007. Epub 2007 Mar 21.

Effect of the Aedes fluviatilis saliva on the development of Plasmodium gallinaceum infection in Gallus (gallus) domesticus

Rocha AC, Braga EM, Araújo MS, Franklin BS, Pimenta PF.

Mem Inst Oswaldo Cruz. 2004 Nov;99(7):709-15. doi: 10.1590/s0074-02762004000700008. Epub 2005 Jan 12.