Florian I. Schmidt Lab

Inflammasome Assembly

Project details

We use a novel inflammasome reporter as well as customized nanobodies to dissect the mechanisms of inflammasome assembly in response to cytosolic evidence of infection or danger. The cooperative assembly of inflammasomes mediates a tunable all-or-nothing reaction and thus achieves maximal sensitivity at appropriate safety.

Project-related publications

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H.

Science. 2020 Sep 18;369(6510):eaas8995. doi: 10.1126/science.aas8995.

Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant

Herlin T, Jørgensen SE, Høst C, Mitchell PS, Christensen MH, Laustsen M, Larsen DA, Schmidt FI, Christiansen M, Mogensen TH.

Rheumatology (Oxford). 2020 Sep 1;59(9):2334-2339. doi: 10.1093/rheumatology/kez612.

From atoms to physiology: what it takes to really understand inflammasomes

Schmidt FI.

J Physiol. 2019 Nov;597(22):5335-5348. doi: 10.1113/JP277027. Epub 2019 Nov 4.

The intra- and extracellular functions of ASC specks

Franklin BS, Latz E, Schmidt FI.

Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611.

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H.

Nat Struct Mol Biol. 2016 May;23(5):416-25. doi: 10.1038/nsmb.3199. Epub 2016 Apr 4.

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL.

J Exp Med. 2016 May 2;213(5):771-90. doi: 10.1084/jem.20151790. Epub 2016 Apr 11.

Project-related funding


Deutsche Forschungsgemeinschaft (DFG)

SPP 1923

Deutsche Forschungsgemeinschaft (DFG)

Emmy Noether Programme

Deutsche Forschungsgemeinschaft (DFG)

Project-related scientists

Florian Schmidt Lab
Florian Schmidt Lab
Florian Schmidt Lab
Florian Schmidt Lab
Florian Schmidt Lab
Florian Schmidt Lab

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