Florian Schmidt Lab Publications

ScienceTeamPublications

Publication metrics Florian Schmidt
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Total citations: 2452
H-Index: 23

Selected publications

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI

J Exp Med 2 January 2023; 220 (1): e20220837

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.

EMBO Mol Med. 2022 Jun 8;14(6):e15415.

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI.

Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12.

Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies

Schmidt FI.

Methods Mol Biol. 2018;1836:139-158. doi: 10.1007/978-1-4939-8678-1_7.

Selected Reviews

From atoms to physiology: what it takes to really understand inflammasomes

Schmidt FI.

J Physiol. 2019 Nov;597(22):5335-5348. doi: 10.1113/JP277027. Epub 2019 Nov 4.

All publications

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ

Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI

J Exp Med 2 January 2023; 220 (1): e20220837

Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus

Steiner A, Reygaerts T, Pontillo A, Ceccherini I, Moecking J, Moghaddas F, Davidson S, Caroli F, Grossi A, Castro FFM, Kalil J, Gohr FN, Schmidt FI, Bartok E, Zillinger T, Hartmann G, Geyer M, Gattorno M, Mendonça LO, Masters SL.

J Clin Immunol. 2022 Feb;42(2):325-335.

Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice

Dhana E, Klaus D, Böhner A, Schmidt F, von Vietinghoff S, Boor P, Djudjaj S, Kurts C

Immunol Methods. 2022 Aug;507:113310

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.

EMBO Mol Med. 2022 Jun 8;14(6):e15415.

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI.

Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12.

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

Krämer B, Knoll R, Bonaguro L, ToVinh M, Raabe J, Astaburuaga-García R, Schulte-Schrepping J, Kaiser KM, Rieke GJ, Bischoff J, Monin MB, Hoffmeister C, Schlabe S, De Domenico E, Reusch N, Händler K, Reynolds G, Blüthgen N, Hack G, Finnemann C, Nischalke HD, Strassburg CP, Stephenson E, Su Y, Gardner L, Yuan D, Chen D, Goldman J, Rosenstiel P, Schmidt SV, Latz E, Hrusovsky K, Ball AJ, Johnson JM, Koenig PA, Schmidt FI, Haniffa M, Heath JR, Kümmerer BM, Keitel V, Jensen B, Stubbemann P, Kurth F, Sander LE, Sawitzki B

Immunity. 2021 Nov 9;54(11):2650-2669.e14.

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H.

Science. 2020 Sep 18;369(6510):eaas8995. doi: 10.1126/science.aas8995.

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Bosso M, Prelli Bozzo C, Hotter D, Volcic M, Stürzel CM, Rammelt A, Ni Y, Urban S, Becker M, Schelhaas M, Wittmann S, Christensen MH, Schmidt FI, Gramberg T, Sparrer KMJ, Sauter D, Kirchhoff F.

PLoS Pathog. 2020 Aug 6;16(8):e1008752. doi: 10.1371/journal.ppat.1008752. eCollection 2020 Aug.

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D.

Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907.

Jack of all trades inhibits inflammation (in sober people)

Schmidt FI, Latz E.

Nat Immunol. 2020 Jul;21(7):718-719. doi: 10.1038/s41590-020-0693-6.

Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant

Herlin T, Jørgensen SE, Høst C, Mitchell PS, Christensen MH, Laustsen M, Larsen DA, Schmidt FI, Christiansen M, Mogensen TH.

Rheumatology (Oxford). 2020 Sep 1;59(9):2334-2339. doi: 10.1093/rheumatology/kez612.

From atoms to physiology: what it takes to really understand inflammasomes

Schmidt FI.

J Physiol. 2019 Nov;597(22):5335-5348. doi: 10.1113/JP277027. Epub 2019 Nov 4.

Exploiting Nanobodies' Singular Traits

Ingram JR, Schmidt FI, Ploegh HL.

Annu Rev Immunol. 2018 Apr 26;36:695-715. doi: 10.1146/annurev-immunol-042617-053327. Epub 2018 Feb 28.

The intra- and extracellular functions of ASC specks

Franklin BS, Latz E, Schmidt FI.

Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611.

Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies

Schmidt FI.

Methods Mol Biol. 2018;1836:139-158. doi: 10.1007/978-1-4939-8678-1_7.

Localized CD47 blockade enhances immunotherapy for murine melanoma

Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10184-10189. doi: 10.1073/pnas.1710776114. Epub 2017 Sep 5.

Editorial: Crystal death: it's not always the inflammasome..

Schmidt FI, Ploegh HL.

J Leukoc Biol. 2017 Jul;102(1):1-4. doi: 10.1189/jlb.3CE0117-022R.

CD14-New Tricks of an Old Acquaintance

Schmidt FI, Latz E.

Immunity. 2017 Oct 17;47(4):606-608. doi: 10.1016/j.immuni.2017.10.003.

Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication

Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL.

EMBO Rep. 2017 Jun;18(6):1027-1037. doi: 10.15252/embr.201643764. Epub 2017 Apr 10.

Phenotypic lentivirus screens to identify functional single domain antibodies

Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL.

Nat Microbiol. 2016 Jun 20;1(8):16080. doi: 10.1038/nmicrobiol.2016.80.

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H.

Nat Struct Mol Biol. 2016 May;23(5):416-25. doi: 10.1038/nsmb.3199. Epub 2016 Apr 4.

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL.

mBio. 2016 Dec 13;7(6):e01569-16. doi: 10.1128/mBio.01569-16.

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL.

J Exp Med. 2016 May 2;213(5):771-90. doi: 10.1084/jem.20151790. Epub 2016 Apr 11.

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL.

PLoS Pathog. 2015 Oct 2;11(10):e1005188. doi: 10.1371/journal.ppat.1005188. eCollection 2015 Oct.

Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization

Ashour J, Schmidt FI, Hanke L, Cragnolini J, Cavallari M, Altenburg A, Brewer R, Ingram J, Shoemaker C, Ploegh HL.

J Virol. 2015 Mar;89(5):2792-800. doi: 10.1128/JVI.02693-14. Epub 2014 Dec 24.

The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice

Koenig PA, Nicholls PK, Schmidt FI, Hagiwara M, Maruyama T, Frydman GH, Watson N, Page DC, Ploegh HL.

J Biol Chem. 2014 Dec 12;289(50):34490-502. doi: 10.1074/jbc.M114.604132. Epub 2014 Oct 15.

siRNA screen of early poxvirus genes identifies the AAA+ ATPase D5 as the virus genome-uncoating factor

Kilcher S, Schmidt FI, Schneider C, Kopf M, Helenius A, Mercer J.

Cell Host Microbe. 2014 Jan 15;15(1):103-12. doi: 10.1016/j.chom.2013.12.008.

Single-virus fusion experiments reveal proton influx into vaccinia virions and hemifusion lag times

Schmidt FI, Kuhn P, Robinson T, Mercer J, Dittrich PS.

Biophys J. 2013 Jul 16;105(2):420-31. doi: 10.1016/j.bpj.2013.06.016.

Vaccinia virus entry is followed by core activation and proteasome-mediated release of the immunomodulatory effector VH1 from lateral bodies

Schmidt FI, Bleck CK, Reh L, Novy K, Wollscheid B, Helenius A, Stahlberg H, Mercer J.

Cell Rep. 2013 Aug 15;4(3):464-76. doi: 10.1016/j.celrep.2013.06.028. Epub 2013 Jul 25.

Poxvirus host cell entry

Schmidt FI, Bleck CK, Mercer J.

Curr Opin Virol. 2012 Feb;2(1):20-7. doi: 10.1016/j.coviro.2011.11.007. Epub 2011 Dec 27.

Vaccinia virus egress: actin OUT with clathrin

Schmidt FI, Mercer J.

Cell Host Microbe. 2012 Sep 13;12(3):263-5. doi: 10.1016/j.chom.2012.08.007.

Cooperative vaccinia infection demonstrated at the single-cell level using FluidFM

Stiefel P, Schmidt FI, Dörig P, Behr P, Zambelli T, Vorholt JA, Mercer J.

Nano Lett. 2012 Aug 8;12(8):4219-27. doi: 10.1021/nl3018109. Epub 2012 Jul 2.

A facile protocol for the immobilisation of vesicles, virus particles, bacteria, and yeast cells

Kuhn P, Eyer K, Robinson T, Schmidt FI, Mercer J, Dittrich PS.

Integr Biol (Camb). 2012 Dec;4(12):1550-5. doi: 10.1039/c2ib20181j.

Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture

Schmidt FI, Bleck CK, Helenius A, Mercer J.

EMBO J. 2011 Jul 26;30(17):3647-61. doi: 10.1038/emboj.2011.245.

Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry

Mercer J, Knébel S, Schmidt FI, Crouse J, Burkard C, Helenius A.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9346-51. doi: 10.1073/pnas.1004618107. Epub 2010 May 3.

Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding

Hara K, Schmidt FI, Crow M, Brownlee GG.

J Virol. 2006 Aug;80(16):7789-98. doi: 10.1128/JVI.00600-06.

Institute of Innate Immunity
University Hospital Bonn
Biomedical Center (BMZ 2)
Building 12
2G
Venusberg-Campus 1
53127 Bonn, Germany

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