Research Funding of the Institute of Innate Immunity

We are grateful for the funding agencies to support our research.

Excellence Cluster ImmunoSensation2

Deutsche Forschungsgemeinschaft (DFG)
http://www.immunosensation.de
Project ID: EXC2151 – 390873048

ImmunoSensation2 is a DFG-funded Cluster of Excellence dedicated to investigating innate immunity beyond the boundaries of classical immunology, which we term the immune sensory system. Our scientists include immunologists, neurobiologists, system biologists and mathematicians from University of Bonn Medical Faculty and Faculty of Mathematics and Natural Sciences and the German Center for Neurodegenerative Diseases (DZNE) of the Helmholtz-Society.Founded in 2012, ImmunoSensation is currently in its ninth year of funding, and we continue to pursue our mission of innovative science in immunology, with a focus on connecting immunology to other systems, such as the metabolic system and the nervous system, and better understanding the intimate connection between the immune sensory system and human health and disease.‍

SFB 1123

Deutsche Forschungsgemeinschaft (DFG)
322568668

Our data provide evidence that the inflammasome members Nlrp3 and Nlrp6 promote opposing functions in atherogenesis. We found that NLRP3 serves as “early sensor” for high fat western diet (WD) and initiates epigenetic changes and advanced onset of atherosclerotic disease, whereas NLRP6 protects the host, possibly by maintaining intestinal immune homeostasis. Here, we aim at identifying active NLRP3 and NLRP6 inflammasomes during WD (Aim 1), metabolic evaluation of the gut-liver-atheroma axis in a hypercholesteremic environment (Aim 2), and deciphering NLRP6-based influences on the epigenetic landscape in the early onset of atherosclerotic disease (Aim 3).

Projects

TP B07

Eicke Latz/ Peter Düwell

Gottfried Wilhelm Leibniz-Preis

Deutsche Forschungsgemeinschaft (DFG)
https://www.dfg.de/gefoerderte_projekte/wissenschaftliche_preise/leibniz-preis/
322568668

Award recipient

Eicke Latz

Emmy Noether Programme

Deutsche Forschungsgemeinschaft (DFG)
https://www.dfg.de/foerderung/programme/einzelfoerderung/emmy_noether/index.html
322568668

Grant recipients

Florian I. Schmidt

SFB TRR 83

Deutsche Forschungsgemeinschaft (DFG)
https://www.trr83.de/
322568668

Biological membranes with their two key constituents - proteins and lipids - mediate an astonishing array of functions ranging from simple barriers to complex signal transduction platforms. In contrast to an aqueous solution, where protein interactions are controlled by a single solvent - water -, lipid bilayers contain hundreds of different acyl chains and head groups providing distinct amphipathic interfaces and thus open another dimension to create architectural and functional diversity. The central aims of the TRR 83 are to characterize the molecular composition and structural organization of distinct membrane domains, to elucidate their physical and chemical properties and to understand their physiological functions. The TRR 83 joins scientists from three locations – Bonn, Dresden, and Heidelberg – and has significantly advanced the current status in lipid analysis, lipid imaging, and lipid cross-linking by developing various new chemical tools.

Grant recipients

TP21

Eicke Latz

TP28

Dagmar Wachten

SPP 1926

Deutsche Forschungsgemeinschaft (DFG)
https://spp1926.de
322568668

In recent years, optogenetics revolutionized research in neuroscience and is now transforming also cell biology. Genetically encoded or addressable, light-controlled proteins or molecules are introduced in heterologous cells, tissue or whole animals to enable temporally precise and largely non-invasive control of molecular, cellular, or network activities.

Grant recipient

Dagmar Wachten

SPP 1726

DFG
https://www.SPP1726.de
322568668

The aim of the priority programme is to coherently combine the research activities on microswimmers in biology, biophysics, theoretical and experimental soft matter physics, and simulation sciences. Advanced experimental techniques, new nanotechnological tools, soft-matter chemistry and physics, and novel simulation approaches promise deeper insights into the underlying physical and bio-chemical processes, and provide the tools to design and construct new artificial microswimmers.

Grant recipient

Dagmar Wachten

FOR 2743

Deutsche Forschungsgemeinschaft (DFG)
https://www.for2743.uni-bonn.de/
322568668

The cells and tissues of our body are constantly subjected to stress resulting from mechanical forces. Skeletal muscles and heart generate such forces. Skin and bones have to withstand them. The kidney filtrates our blood under constant mechanical stress resulting from the blood pressure. And even the migration of cells for example during immune defence or tumour invasion is influenced by mechanical forces. The research unit investigates how cells and tissues cope with mechanical stress.

Grant recipient

P7 Dagmar Wachten / Waldemar Kolanus

SFB 914

Deutsche Forschungsgemeinschaft (DFG)
https://www.sfb914.de
322568668

Grant recipient

Felix Meissner

SFB 1335

Deutsche Forschungsgemeinschaft (DFG)
https://www.sfb1335.de
322568668

Grant recipient

Felix Meissner

SFB TRR 274

Deutsche Forschungsgemeinschaft (DFG)
https://www.sfb274.de
322568668

Grant recipient

Felix Meissner

SFB TRR 237

Deutsche Forschungsgemeinschaft (DFG)
https://www.trr237.uni-bonn.de
369799452 – TRR237

Scientists working in the TRR 237 are interested in gaining new insights into the molecular mechanisms involved in the defense against nucleic acids. Currently, there are 21 research projects that collaboratively address several overarching questions in the field of nucleic acid sensing.

Grant recipients

A01

Florian I. Schmidt/Gunther Hartmann

A11

Eicke Latz

SFB 1403

Deutsche Forschungsgemeinschaft (DFG)
https://sfb1403.uni-koeln.de
Project ID: 414786233 - SFB1403

The projects within SFB1403 study the mechanisms regulating cell death and its impact on immunity, host-microbe interactions, inflammation and disease.

Grant recipients

A04

Eicke Latz/Florian I. Schmidt

SFB 1454

Deutsche Forschungsgemeinschaft (DFG)
322568668

Projects

P01

Karsten Hiller/Eicke Latz

P03

Eicke Latz

P11

Felix Meissner

P18

Dagmar Wachten

P20

Bianca Martin/Monique Breteler

Ö01

Annette Christ/Clemens Albrecht/Moritz von Stetten

IRTG 2168

Deutsche Forschungsgemeinschaft
https://bonnmelb-phdprogram.com
322568668

Bonn & Melbourne Research and Graduate School Immunosciences

Projects

TP 09

Eicke Latz

TP06

Susanne Schmidt

TP12

Florian I. Schmidt

SPP 1923

Deutsche Forschungsgemeinschaft (DFG)
https://spp1923.de
322568668

Retroviruses comprise a diverse group of exogenous and endogenous viruses defined by their unique replication strategy to reverse-transcribe their RNA genome into a complementary DNA. Millions of years of coevolution with their mammalian hosts gave rise to highly pathogenic as well as apathogenic members of this family of viruses and to species-specific differences in their pathologic potential. Evidence is emerging that cell-type specific cell-autonomous components of the innate immune system, including specialized pattern recognition receptors and broadly active antiviral restriction factors, represent key determinants of the fundamentally different outcomes of retroviral infections. However, the specific host cell machineries involved in recognizing retroviral infection, viral evasion strategies thereof, and their relative contribution to retroviral pathogenesis in specific target cells and organs remain to be defined. Priority Program SPP1923 (Innate sensing of restriction of retroviruses) thus aims at the identification of the full molecular sensing and restriction machinery involved in cell-autonomous immunity against retroviruses, its regulation, virus-encoded countermeasures, and pathophysiological consequences. During the first funding period of SPP1923, a strong collaborative research and training network of retrovirologists and innate immunologists was developed that defined novel important molecular mechanisms and cell-type or species-specific principles of retroviral sensing and restriction of retroviruses. Work during the second funding period will build on these findings and the interdisciplinary network established with the goal to gain detailed molecular and physiological understanding of these processes. Central funds are requested for an SPP office that assists the SPP coordinator in managing SPP activities and for networking activities such as SPP internal meetings, workshops, exchange of co-workers and an international SPP conference.

Projects

Investigation of Innate ImmuneResponses against HIV with Camelid Nanobodies

Eicke Latz/ Florian I. Schmidt

Mechanisms of inflammasome activationand pyroptosis induction by HIV
‍Eicke Latz

BMBF-Wissenschaft im Dialog

322568668

COVIMMUNE

BMBF
https://www.gesundheitsforschung-bmbf.de/de/untersuchungen-zur-funktion-des-immunsystems-und-krankheitsverlauf-von-covid-19-12078.php
322568668

In this consortium clinicians involved in COVID-19 patient care at the University Hospital Bonn work together with basic scientists with expertise in immunology from the Medical Faculty of the University of Bonn to achieve a better understanding of the divergent host responses to SARS-CoV-2 infection. In three interconnected subprojects COVIMMUNE will perform a systems approach to assess how the cellular and humoral innate and adaptive immune responses to SARS-Cov-2 infection contribute to the immediate and long-term clinical outcome of COVID-19. The consortium has access to large pre-existing and prospective cohorts of patients with asymptomatic, mild and severe COVID-19 disease and through longitudinal profiling of the immune response will be able to mechanistically link the immune response to the clinical outcome of the disease.

Grant recipient

Eicke Latz (PI)

BMBF CTAP

BMBF
322568668

Grant recipient

Felix Meissner

ERC starting grant

European Research Council
322568668

Grant recipient

Bernardo Franklin

ERC Consolidator grant

European Research Council
322568668

Grant recipient

Eicke Latz

GIF

German-Israeli Foundation
322568668

Grant recipient

Felix Meissner

Horizon 2020 research and innovation programme

European Commission
https://www.to-aition.eu
EU project ID 848146

Depression is highly associated with cardiovascular disease (CVD), significantly increasing the risk of CVD development, acute events and mortality, especially in women. As a consequence, it represents a social and economic issue affecting the patient’s life and causing healthcare costs to rise. However, the mechanisms and progression of the disease remain unknown. The EU-funded TO_AITION project works on the hypothesis that immune-metabolic dysregulation due to genetic, lifestyle and environmental risk factors affects immunity mechanisms leading to CVD-associated depression. The project will effectuate basic, preclinical and clinical research applying data-driven strategies to detect and describe immune-metabolic mechanisms responsible for CVD-depression comorbidity, aiming to improve diagnosis and management of the disease.

Chad Tough Foundation

322568668

Klaus Tschira Boost Fund

Klaus Tschira Boost Fund
https://gsonet.org/funding-programs/klaus-tschira-boost-fund/?lang=en
322568668

Grant recipients

Florian I. Schmidt

Boehringer Ingelheim Fonds

Boehringer Ingelheim Fonds
https://www.bifonds.de/
322568668

Grant recipient

Jan Niklas Hansen

EFSD/ Boehringer Ingelheim

European Foundation for the Study of Diabetes/ Boehringer Ingelheim
http://www.EuropeanDiabetesFoundation.org
322568668

Funding University of Bonn

University of Bonn
322568668

Collaborative Research Grant between the University of Bonn and Emory University, USA

Grant recipient

Dagmar Wachten (Bonn)

Tamara Caspary (Emory)

Medical Faculty

Medical Faculty, University of Bonn
322568668

Translational Development of Camelid Nanobodies Neutralizing SARS-CoV-2

Grant recipient

Florian I. Schmidt

Intramural Funding from the Medical Faculty

Universitätsklinikum Bonn
322568668

Brigitte und Dr. Konstanze Wegener-Stiftung

Brigitte und Dr. Konstanze Wegener-Stiftung
https://www.bkwegener-stiftung.de
322568668

SFB TRR57

322568668

Projects

TP 24

Eicke Latz

Bernardo Franklin