Dagmar Wachten  Publications

ScienceTeamPublicationsAlumni


‍All Publications

Selected publications

Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research

Jeannette Gebel, Elisa Ciglieri, Rainer Stahl, Fraser Duthie, Fabian Frechen, Andreas Möglich, Herbert Müller-Hartmann, Hanns-Martin Schmidt, Dagmar Wachten

Nucleic Acids Research 10.1093/nar/gkaf546

Kupffer cell programming by maternal obesity triggers fatty liver disease

Hao Huang, Nora R. Balzer, Lea Seep, Iva Splichalova, Nelli Blank-Stein, Maria Francesca Viola, Eliana Franco Taveras, Kerim Acil, Diana Fink, Franzisca Petrovic, Nikola Makdissi, Seyhmus Bayar, Katharina Mauel, Carolin Radwaniak, Jelena Zurkovic, Amir H. Kayvanjoo, Klaus Wunderling, Malin Jessen, Mohamed H. Yaghmour, Lukas Kenner, Thomas Ulas, Stephan Grein, Joachim L. Schultze, Charlotte L. Scott, Martin Guilliams, Zhaoyuan Liu, Florent Ginhoux, Marc D. Beyer, Christoph Thiele, Felix Meissner, Jan Hasenauer, Dagmar Wachten & Elvira Mass

Nature 10.1038/s41586-025-09190-w

Renal tissue-resident macrophages promote cystogenesis in early polycystic disease

Rudolfo Karl, Arsila Palliyulla Kariat Ashraf, Maria Francesca Viola, Katharina Hopp, Elvira Mass, Dagmar Wachten

Journal of Cell Science 138 10.1242/jcs.263992.

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue

Katharina Sieckmann, Nora Winnerling, Dalila Juliana Silva Ribeiro, Seniz Yüksel, Ronja Kardinal, Lisa Maria Steinheuer, Fabian Frechen, Luis Henrique Corrêa, Geza Schermann, Christina Klausen, Nelli Blank-Stein, Jonas Schulte-Schrepping, Collins Osei-Sarpong, Matthias Becker, Lorenzo Bonaguro, Marc Beyer, Helen Louise May-Simera, Jelena Zurkovic, Christoph Thiele, Kevin Thurley, Lydia Sorokin, Carmen Ruiz de Almodovar, Elvira Mass, Dagmar Wachten

Embo j 10.1038/s44318-025-00524-y

Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.

Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D*, Kornfeld JW*.

Nat Metab. 2024 Jun;6(6):1053-1075

AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Juliana Silva Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN

Mol Biol Cell. 2022 Oct 1;33(12):br22

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

Hansen JN, Kaiser F, Leyendecker P, Stüven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, Händler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D

EMBO Rep. 2022 Aug 3;23(8):e54315

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D.

Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907.

A novel biosensor to study cAMP dynamics in cilia and flagella

Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D.

Elife. 2016 Mar 22;5:e14052. doi: 10.7554/eLife.14052.

Controlling fertilization and cAMP signaling in sperm by optogenetics

Jansen V, Alvarez L, Balbach M, Strünker T, Hegemann P, Kaupp UB, Wachten D.

Elife. 2015 Jan 20;4:e05161. doi: 10.7554/eLife.05161.

Selected Reviews

The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation

N. Jurisch-Yaksi, D. Wachten, J. Gopalakrishnan

Trends Neurosci . 2024 May;47(5):383-394.

Emerging principles of primary cilia dynamics in controlling tissue organization and function

Gopalakrishnan J, Feistel K, Friedrich BM, Grapin-Botton A, Jurisch-Yaksi N, Mass E, Mick DU, Müller RU, May-Simera H, Schermer B, Schmidts M, Walentek P, Wachten D.

EMBO J. 2023 Nov 2;42(21):e113891.

Primary cilia and their effects on immune cell functions and metabolism: a model

Ernesto Picon-Galindo, Eicke Latz, Dagmar Wachten,

Trends Immunol. 2022 May;43(5):366-378

The BBSome: a nexus controlling energy metabolism in the brain

Blaess S, Wachten D.

J Clin Invest. 2021 Apr 15;131(8):148903. doi: 10.1172/JCI148903.

Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling

Wachten D, Mick DU.

Pharmacol Ther. 2021 Aug;224:107836. doi: 10.1016/j.pharmthera.2021.107836

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

Klausen C, Kaiser F, Stüven B, Hansen JN, Wachten D.

Biochem Soc Trans. 2019 Dec 20;47(6):1733-1747. doi: 10.1042/BST20190246.

How to control cyclic nucleotide signaling by light

Jansen V, Jikeli JF, Wachten D.

Curr Opin Biotechnol. 2017 Dec;48:15-20. doi: 10.1016/j.copbio.2017.02.014. Epub 2017 Mar 10.

Institute of Innate Immunity
University Hospital Bonn
Biomedical Center (BMZ 2)
Building 12
2G
Venusberg-Campus 1
53127 Bonn, Germany

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