Dagmar Wachten  Publications

ScienceTeamPublications

Publication metrics Dagmar Wachten
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Total citations: 2181
H-Index: 27

Selected publications

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

Hansen JN, Kaiser F, Leyendecker P, Stüven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, Händler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D

EMBO Rep. 2022 Aug 3;23(8):e54315

AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Juliana Silva Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN

Mol Biol Cell. 2022 Oct 1;33(12):br22

Multifocal imaging for precise, label-free tracking of fast biological processes in 3D

Hansen, JN, Gong, A, Wachten, D, Pascal, R, Turpin, A, Jikeli, JF, Kaup, UB, Alvarez, L

Nat Commun. 2021 Jul 28;12(1):4574. doi: 10.1038/s41467-021-24768-4

Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.

D'Gama PP, Qiu T, Cosacak MI, Rayamajhi D, Konac A, Hansen JN, Ringers C, Acuña-Hinrichsen F, Hui SP, Olstad EW, Chong YL, Lim CKA, Gupta A, Ng CP, Nilges BS, Kashikar ND, Wachten D, Liebl D, Kikuchi K, Kizil C, Yaksi E, Roy S, Jurisch-Yaksi N

Cell Rep. 2021 Oct 5;37(1):109775

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D.

Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907.

A novel biosensor to study cAMP dynamics in cilia and flagella

Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D.

Elife. 2016 Mar 22;5:e14052. doi: 10.7554/eLife.14052.

Controlling fertilization and cAMP signaling in sperm by optogenetics

Jansen V, Alvarez L, Balbach M, Strünker T, Hegemann P, Kaupp UB, Wachten D.

Elife. 2015 Jan 20;4:e05161. doi: 10.7554/eLife.05161.

Selected Reviews

Primary cilia and their effects on immune cell functions and metabolism: a model

Ernesto Picon-Galindo, Eicke Latz, Dagmar Wachten,

Trends Immunol. 2022 May;43(5):366-378

Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling

Wachten D, Mick DU.

Pharmacol Ther. 2021 Aug;224:107836. doi: 10.1016/j.pharmthera.2021.107836

The BBSome: a nexus controlling energy metabolism in the brain

Blaess S, Wachten D.

J Clin Invest. 2021 Apr 15;131(8):148903. doi: 10.1172/JCI148903.

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

Klausen C, Kaiser F, Stüven B, Hansen JN, Wachten D.

Biochem Soc Trans. 2019 Dec 20;47(6):1733-1747. doi: 10.1042/BST20190246.

How to control cyclic nucleotide signaling by light

Jansen V, Jikeli JF, Wachten D.

Curr Opin Biotechnol. 2017 Dec;48:15-20. doi: 10.1016/j.copbio.2017.02.014. Epub 2017 Mar 10.

All publications

Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity

Domingos C, Müller FE, Passlick S, Wachten D, Ponimaskin E, Schwarz MK, Schoch S, Zeug A, Henneberger C.

Cells. 2023 Jan 15;12(2):331.

Primary cilia and their effects on immune cell functions and metabolism: a model

Ernesto Picon-Galindo, Eicke Latz, Dagmar Wachten,

Trends Immunol. 2022 May;43(5):366-378

Measurement of ciliary beating and fluid flow in the zebrafish adult telencephalon

Jeong I, Hansen JN, Wachten D, Jurisch-Yaksi N

STAR Protoc. 2022 Sep 16;3(3):101542. Epub 2022 Jul 16

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

Hansen JN, Kaiser F, Leyendecker P, Stüven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, Händler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D

EMBO Rep. 2022 Aug 3;23(8):e54315

AdipoQ-a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Juliana Silva Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN

Mol Biol Cell. 2022 Oct 1;33(12):br22

Signal transduction in primary cilia - analyzing and manipulating GPCR and second messenger signaling

Wachten D, Mick DU.

Pharmacol Ther. 2021 Aug;224:107836. doi: 10.1016/j.pharmthera.2021.107836

Creld1 regulates myocardial development and function

Beckert V, Rassmann S, Kayvanjoo AH, Klausen C, Bonaguro L, Botermann DS, Krause M, Moreth K, Spielmann N, da Silva-Buttkus P, Fuchs H, Gailus-Durner V, de Angelis MH, Händler K, Ulas T, Aschenbrenner AC, Mass E, Wachten D.

J Mol Cell Cardiol . 2021 Jul;156:45-56. doi: 10.1016/j.yjmcc.2021.03.008. Epub 2021 Mar 24

The BBSome: a nexus controlling energy metabolism in the brain

Blaess S, Wachten D.

J Clin Invest. 2021 Apr 15;131(8):148903. doi: 10.1172/JCI148903.

CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images

Hansen JN, Rassmann S, Stüven B, Jurisch-Yaksi N, Wachten D.

Eur Phys J E Soft Matter. 2021 Mar 8;44(2):18. doi: 10.1140/epje/s10189-021-00031-y.

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

Gadadhar S, Alvarez Viar G, Hansen JN, Gong A, Kostarev A, Ialy-Radio C, Leboucher S, Whitfield M, Ziyyat A, Touré A, Alvarez L, Pigino G, Janke C.

Science. 2021 Jan 8;371(6525):eabd4914. doi: 10.1126/science.abd4914.

Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress.

Beins EC, Beiert T, Jenniches I, Hansen JN, Leidmaa E, Schrickel JW, Zimmer A.

Transl Psychiatry. 2021 Mar 15;11(1):164. doi: 10.1038/s41398-021-01283-0

Results of a completely outpatient autologous stem cell transplant program for lymphoma patients receiving reduced-intensity conditioning.

Jaime-Pérez JC, Hernández-Coronado M, Picón-Galindo E, Salazar-Cavazos L, Gutiérrez-Aguirre CH, Gómez-Almaguer D.

Leuk Lymphoma. 2021 Jan 24:1-10. doi: 10.1080/10428194.2021.1876870.

Maintaining proteostasis under mechanical stress

Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B.

EMBO Rep . 2021 Jul 26;e52507. doi: 10.15252/embr.202152507

Multifocal imaging for precise, label-free tracking of fast biological processes in 3D

Hansen, JN, Gong, A, Wachten, D, Pascal, R, Turpin, A, Jikeli, JF, Kaup, UB, Alvarez, L

Nat Commun. 2021 Jul 28;12(1):4574. doi: 10.1038/s41467-021-24768-4

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, Krapf D, Molina LCP, Santi CM, Hansen JN, Wachten D, Fushimi M, Meinke PT, Buck J, Levin LR

Mol Hum Reprod . 2021 Aug 31;gaab054. doi: 10.1093/molehr/gaab054.

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

Haward F, Maslon MM, Yeyati PL, Bellora N, Hansen JN, Aitken S, Lawson J, von Kriegsheim A, Wachten D, Mill P, Adams IR, Caceres JF

Elife. 2021 Aug 2;10:e65104. doi: 10.7554/eLife.65104

Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain.

D'Gama PP, Qiu T, Cosacak MI, Rayamajhi D, Konac A, Hansen JN, Ringers C, Acuña-Hinrichsen F, Hui SP, Olstad EW, Chong YL, Lim CKA, Gupta A, Ng CP, Nilges BS, Kashikar ND, Wachten D, Liebl D, Kikuchi K, Kizil C, Yaksi E, Roy S, Jurisch-Yaksi N

Cell Rep. 2021 Oct 5;37(1):109775

Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes

Kierzek M, Deal PE, Miller EW, Mukherjee S, Wachten D, Baumann A, Kaupp UB, Strünker T, Brenker C.

Elife. 2021 Dec 3;10:e63129. doi: 10.7554/eLife.63129. Epub ahead of print.

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D.

Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907.

Sphingolipids controlling ciliary and microvillar function

Kaiser F, Huebecker M, Wachten D.

FEBS Lett. 2020 Nov;594(22):3652-3667. doi: 10.1002/1873-3468.13816. Epub 2020 May 29.

Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm

Balbach M, Hamzeh H, Jikeli JF, Brenker C, Schiffer C, Hansen JN, Neugebauer P, Trötschel C, Jovine L, Han L, Florman HM, Kaupp UB, Strünker T, Wachten D.

Front Cell Dev Biol. 2020 Aug 31;8:572735. doi: 10.3389/fcell.2020.572735. eCollection 2020.

Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility

Oura S, Kazi S, Savolainen A, Nozawa K, Castañeda J, Yu Z, Miyata H, Matzuk RM, Hansen JN, Wachten D, Matzuk MM, Prunskaite-Hyyryläinen R.

PLoS Genet. 2020 Aug 12;16(8):e1008954. doi: 10.1371/journal.pgen.1008954. eCollection 2020 Aug.

Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca(2+) signaling

Schiffer C, Rieger S, Brenker C, Young S, Hamzeh H, Wachten D, Tüttelmann F, Röpke A, Kaupp UB, Wang T, Wagner A, Krallmann C, Kliesch S, Fallnich C, Strünker T.

EMBO J. 2020 Feb 17;39(4):e102363. doi: 10.15252/embj.2019102363. Epub 2020 Jan 19.

Author Correction: Sensory primary cilium is a responsive cAMP microdomain in renal epithelia

Sherpa RT, Mohieldin AM, Pala R, Wachten D, Ostrom RS, Nauli SM.

Sci Rep. 2020 Jan 29;10(1):1731. doi: 10.1038/s41598-020-58754-5.

Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice

Klaus C, Hansen JN, Ginolhac A, Gérard D, Gnanapragassam VS, Horstkorte R, Rossdam C, Buettner FFR, Sauter T, Sinkkonen L, Neumann H, Linnartz-Gerlach B

Neurobiol Aging. 2020 Apr;88:91-107. doi: 10.1016/j.neurobiolaging.2020.01.008. Epub 2020 Jan 21.

Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm

Balbach Melanie, Hamzeh Hussein, Jikeli Jan F., Brenker Christoph, Schiffer Christian, Hansen Jan N., Neugebauer Pia, Trötschel Christian, Jovine Luca, Han Ling, Florman Harvey M., Kaupp U. Benjamin, Strünker Timo, Wachten Dagmar

Front. Cell Dev. Biol., 31 August 2020

Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models

Guo J, Otis JM, Suciu SK, Catalano C, Xing L, Constable S, Wachten D, Gupton S, Lee J, Lee A, Blackley KH, Ptacek T, Simon JM, Schurmans S, Stuber GD, Caspary T, Anton ES.

Dev Cell. 2019 Dec 16;51(6):759-774.e5. doi: 10.1016/j.devcel.2019.11.005.

Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development

Olstad EW, Ringers C, Hansen JN, Wens A, Brandt C, Wachten D, Yaksi E, Jurisch-Yaksi N.

Curr Biol. 2019 Jan 21;29(2):229-241.e6. doi: 10.1016/j.cub.2018.11.059. Epub 2019 Jan 3.

Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases

Stabel R, Stüven B, Hansen JN, Körschen HG, Wachten D, Möglich A.

J Mol Biol. 2019 Aug 9;431(17):3029-3045. doi: 10.1016/j.jmb.2019.07.011. Epub 2019 Jul 10.

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

Klausen C, Kaiser F, Stüven B, Hansen JN, Wachten D.

Biochem Soc Trans. 2019 Dec 20;47(6):1733-1747. doi: 10.1042/BST20190246.

Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains

Raju DN, Hansen JN, Rassmann S, Stüven B, Jikeli JF, Strünker T, Körschen HG, Möglich A, Wachten D.

Cells. 2019 Jun 27;8(7):648. doi: 10.3390/cells8070648.

Sensory primary cilium is a responsive cAMP microdomain in renal epithelia

Sherpa RT, Mohieldin AM, Pala R, Wachten D, Ostrom RS, Nauli SM.

Sci Rep. 2019 Apr 25;9(1):6523. doi: 10.1038/s41598-019-43002-2.

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations

Woeste MA, Stern S, Raju DN, Grahn E, Dittmann D, Gutbrod K, Dörmann P, Hansen JN, Schonauer S, Marx CE, Hamzeh H, Körschen HG, Aerts JMFG, Bönigk W, Endepols H, Sandhoff R, Geyer M, Berger TK, Bradke F, Wachten D.

J Biol Chem. 2019 Mar 15;294(11):3853-3871. doi: 10.1074/jbc.RA118.006311. Epub 2019 Jan 20.

Characterization and engineering of photoactivated adenylyl cyclases

Stüven B, Stabel R, Ohlendorf R, Beck J, Schubert R, Möglich A

Biol Chem. 2019 Feb 25;400(3):429-441. doi: 10.1515/hsz-2018-0375

Shedding light on the role of cAMP in mammalian sperm physiology

Balbach M, Beckert V, Hansen JN, Wachten D.

Mol Cell Endocrinol. 2018 Jun 15;468:111-120. doi: 10.1016/j.mce.2017.11.008. Epub 2017 Nov 13.

A novel cross-species inhibitor to study the function of CatSper Ca(2+) channels in sperm

Rennhack A, Schiffer C, Brenker C, Fridman D, Nitao ET, Cheng YM, Tamburrino L, Balbach M, Stölting G, Berger TK, Kierzek M, Alvarez L, Wachten D, Zeng XH, Baldi E, Publicover SJ, Kaupp UB, Strünker T.

Br J Pharmacol. 2018 Aug;175(15):3144-3161. doi: 10.1111/bph.14355. Epub 2018 Jun 29.

SpermQ⁻A Simple Analysis Software to Comprehensively Study Flagellar Beating and Sperm Steering

Hansen JN, Rassmann S, Jikeli JF, Wachten D.

Cells. 2018 Dec 26;8(1):10. doi: 10.3390/cells8010010.

Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes

Smyrnias I, Goodwin N, Wachten D, Skogestad J, Aronsen JM, Robinson EL, Demydenko K, Segonds-Pichon A, Oxley D, Sadayappan S, Sipido K, Bootman MD, Roderick HL.

J Mol Cell Cardiol. 2018 Apr;117:1-18. doi: 10.1016/j.yjmcc.2018.02.012. Epub 2018 Feb 19.

Sperm Sensory Signaling

Wachten D, Jikeli JF, Kaupp UB.

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):a028225. doi: 10.1101/cshperspect.a028225.

How to control cyclic nucleotide signaling by light

Jansen V, Jikeli JF, Wachten D.

Curr Opin Biotechnol. 2017 Dec;48:15-20. doi: 10.1016/j.copbio.2017.02.014. Epub 2017 Mar 10.

The Enigmatic Role of GBA2 in Controlling Locomotor Function

Woeste MA, Wachten D.

Front Mol Neurosci. 2017 Nov 28;10:386. doi: 10.3389/fnmol.2017.00386. eCollection 2017.

Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals

von Gerichten J, Schlosser K, Lamprecht D, Morace I, Eckhardt M, Wachten D, Jennemann R, Gröne HJ, Mack M, Sandhoff R.

J Lipid Res. 2017 Jun;58(6):1247-1258. doi: 10.1194/jlr.D076190. Epub 2017 Apr 3.

Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating

Berger TK, Fußhöller DM, Goodwin N, Bönigk W, Müller A, Dokani Khesroshahi N, Brenker C, Wachten D, Krause E, Kaupp UB, Strünker T.

J Physiol. 2017 Mar 1;595(5):1533-1546. doi: 10.1113/JP273189. Epub 2017 Jan 15.

Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida

Körschgen H, Kuske M, Karmilin K, Yiallouros I, Balbach M, Floehr J, Wachten D, Jahnen-Dechent W, Stöcker W.

Mol Hum Reprod. 2017 Sep 1;23(9):607-616. doi: 10.1093/molehr/gax040.

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease

Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D.

J Biol Chem. 2017 Apr 14;292(15):6177-6189. doi: 10.1074/jbc.M116.762831. Epub 2017 Mar 3.

A novel biosensor to study cAMP dynamics in cilia and flagella

Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D.

Elife. 2016 Mar 22;5:e14052. doi: 10.7554/eLife.14052.

Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile

Schneider S, Balbach M, Jan F Jikeli, Fietz D, Nettersheim D, Jostes S, Schmidt R, Kressin M, Bergmann M, Wachten D, Steger K, Schorle H.

Sci Rep. 2016 Nov 11;6:36764. doi: 10.1038/srep36764.

Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding

Björkgren I, Alvarez L, Blank N, Balbach M, Turunen H, Laajala TD, Toivanen J, Krutskikh A, Wahlberg N, Huhtaniemi I, Poutanen M, Wachten D, Sipilä P.

Mol Cell Endocrinol. 2016 May 15;427:143-54. doi: 10.1016/j.mce.2016.03.013. Epub 2016 Mar 14.

Controlling fertilization and cAMP signaling in sperm by optogenetics

Jansen V, Alvarez L, Balbach M, Strünker T, Hegemann P, Kaupp UB, Wachten D.

Elife. 2015 Jan 20;4:e05161. doi: 10.7554/eLife.05161.

Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics

Raju D, Schonauer S, Hamzeh H, Flynn KC, Bradke F, Vom Dorp K, Dörmann P, Yildiz Y, Trötschel C, Poetsch A, Breiden B, Sandhoff K, Körschen HG, Wachten D.

PLoS Genet. 2015 Mar 24;11(3):e1005063. doi: 10.1371/journal.pgen.1005063. eCollection 2015 Mar.

Direct action of endocrine disrupting chemicals on human sperm

Schiffer C, Müller A, Egeberg DL, Alvarez L, Brenker C, Rehfeld A, Frederiksen H, Wäschle B, Kaupp UB, Balbach M, Wachten D, Skakkebaek NE, Almstrup K, Strünker T.

EMBO Rep. 2014 Jul;15(7):758-65. doi: 10.15252/embr.201438869. Epub 2014 May 12.

Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling

Mass E, Wachten D, Aschenbrenner AC, Voelzmann A, Hoch M.

Dev Cell. 2014 Mar 31;28(6):711-26. doi: 10.1016/j.devcel.2014.02.012.

1-O-acylceramides are natural components of human and mouse epidermis

Rabionet M, Bayerle A, Marsching C, Jennemann R, Gröne HJ, Yildiz Y, Wachten D, Shaw W, Shayman JA, Sandhoff R.

J Lipid Res. 2013 Dec;54(12):3312-21. doi: 10.1194/jlr.M040097. Epub 2013 Sep 27.

CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending

Krähling AM, Alvarez L, Debowski K, Van Q, Gunkel M, Irsen S, Al-Amoudi A, Strünker T, Kremmer E, Krause E, Voigt I, Wörtge S, Waisman A, Weyand I, Seifert R, Kaupp UB, Wachten D.

PLoS Genet. 2013;9(12):e1003960. doi: 10.1371/journal.pgen.1003960. Epub 2013 Dec 5.

The non-lysosomal β-glucosidase GBA2 is a non-integral membrane-associated protein at the endoplasmic reticulum (ER) and Golgi

Körschen HG, Yildiz Y, Raju DN, Schonauer S, Bönigk W, Jansen V, Kremmer E, Kaupp UB, Wachten D.

J Biol Chem. 2013 Feb 1;288(5):3381-93. doi: 10.1074/jbc.M112.414714. Epub 2012 Dec 17.

Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy

Drawnel FM, Wachten D, Molkentin JD, Maillet M, Aronsen JM, Swift F, Sjaastad I, Liu N, Catalucci D, Mikoshiba K, Hisatsune C, Okkenhaug H, Andrews SR, Bootman MD, Roderick HL.

J Cell Biol. 2012 Nov 26;199(5):783-98. doi: 10.1083/jcb.201111095. Epub 2012 Nov 19.

Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes

Harzheim D, Talasila A, Movassagh M, Foo RS, Figg N, Bootman MD, Roderick HL.

Channels (Austin). 2010 Jan-Feb;4(1):67-71. doi: 10.4161/chan.4.1.10531. Epub 2010 Jan 17.

Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and inotropic stimulation

Smyrnias I, Mair W, Harzheim D, Walker SA, Roderick HL, Bootman MD.

Cell Calcium. 2010 Mar;47(3):210-23. doi: 10.1016/j.ceca.2009.10.001. Epub 2010 Jan 27.

Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy

Harzheim D, Movassagh M, Foo RS, Ritter O, Tashfeen A, Conway SJ, Bootman MD, Roderick HL.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11406-11. doi: 10.1073/pnas.0905485106. Epub 2009 Jun 23.

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP

Harzheim D, Pfeiffer KH, Fabritz L, Kremmer E, Buch T, Waisman A, Kirchhof P, Kaupp UB, Seifert R.

EMBO J. 2008 Feb 20;27(4):692-703. doi: 10.1038/emboj.2008.3. Epub 2008 Jan 24.

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1

Bootman MD, Harzheim D, Smyrnias I, Conway SJ, Roderick HL.

Cell Calcium. 2007 Oct-Nov;42(4-5):489-501. doi: 10.1016/j.ceca.2007.05.004. Epub 2007 Jun 14.

Institute of Innate Immunity
University Hospital Bonn
Biomedical Center (BMZ 2)
Building 12
2G
Venusberg-Campus 1
53127 Bonn, Germany

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