Using camelid-derived single-domain antibodies (VHH or nanobody) targeting the adaptor protein ASC, our team has recentlydemonstrated the role of post-pyroptotic ASC specks in the development ofpro-inflammatory diseases. VHHASC disrupt post-pyroptoticspecks – that is, either inside pyroptotic cells or once released from dyingcells – and prevent the unwanted perpetuation of inflammation that theytrigger.
Read more here: https://doi.org/10.15252/emmm.202115415
Press release: https://www.uni-bonn.de/en/news/075-2022
Image: The team was also invited to design the journal cover in collaboration with EMBO Press!