Wachten laboratory

Cell-cell communication

immune and non-immune cells

Project details

We study the interaction of innate immune cells with other cells in a tissue context. To this end, we use mouse models and human cells to understand the crosstalk between immune and non-immune cells under physiological and pathological conditions, e.g., metaflammation.

Project-related publications

Creld1 regulates myocardial development and function

Beckert V, Rassmann S, Kayvanjoo AH, Klausen C, Bonaguro L, Botermann DS, Krause M, Moreth K, Spielmann N, da Silva-Buttkus P, Fuchs H, Gailus-Durner V, de Angelis MH, Händler K, Ulas T, Aschenbrenner AC, Mass E, Wachten D.

J Mol Cell Cardiol . 2021 Jul;156:45-56. doi: 10.1016/j.yjmcc.2021.03.008. Epub 2021 Mar 24

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D.

Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907.

Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models

Guo J, Otis JM, Suciu SK, Catalano C, Xing L, Constable S, Wachten D, Gupton S, Lee J, Lee A, Blackley KH, Ptacek T, Simon JM, Schurmans S, Stuber GD, Caspary T, Anton ES.

Dev Cell. 2019 Dec 16;51(6):759-774.e5. doi: 10.1016/j.devcel.2019.11.005.

Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development

Olstad EW, Ringers C, Hansen JN, Wens A, Brandt C, Wachten D, Yaksi E, Jurisch-Yaksi N.

Curr Biol. 2019 Jan 21;29(2):229-241.e6. doi: 10.1016/j.cub.2018.11.059. Epub 2019 Jan 3.

Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling

Mass E, Wachten D, Aschenbrenner AC, Voelzmann A, Hoch M.

Dev Cell. 2014 Mar 31;28(6):711-26. doi: 10.1016/j.devcel.2014.02.012.

Project-related funding

Intramural Funding from the Medical Faculty

Universitätsklinikum Bonn

SFB 1454

Deutsche Forschungsgemeinschaft (DFG)

Project-related scientists

Dagmar Wachten Lab

Other Projects

Cilia

Optogenetics

Image analysis

Lipid-protein interactions

Wachten laboratory

Cell-cell communication

Project details

Project-related publications

Creld1 regulates myocardial development and function

J Mol Cell Cardiol . 2021 Jul;156:45-56. doi: 10.1016/j.yjmcc.2021.03.008. Epub 2021 Mar 24

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Elife. 2020 Jun 24;9:e57907. doi: 10.7554/eLife.57907.

Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models

Dev Cell. 2019 Dec 16;51(6):759-774.e5. doi: 10.1016/j.devcel.2019.11.005.

Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development

Curr Biol. 2019 Jan 21;29(2):229-241.e6. doi: 10.1016/j.cub.2018.11.059. Epub 2019 Jan 3.

Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling

Dev Cell. 2014 Mar 31;28(6):711-26. doi: 10.1016/j.devcel.2014.02.012.

Project-related funding

Intramural Funding from the Medical Faculty

SFB 1454

Project-related scientists

Nora Louise Winnerling

Dagmar Wachten Lab

Philipp Leyendecker

Dagmar Wachten Lab

Mylene Hübecker, PhD

Dagmar Wachten Lab

Katharina Sieckmann

Dagmar Wachten Lab

Christina Klausen, PhD

Dagmar Wachten Lab

Kim Melina Dreßler

Dagmar Wachten Lab

Ernesto Picòn-Galindo

Dagmar Wachten Lab

Lara-Marie Vagliano

Dagmar Wachten Lab

Other Projects