AG Franklin Lab

Platelet-Immune Cell Interactions and Immunity

Coagulation and Innate Immunity Crosstalk

Project details

In this project, we study how the interaction of platelets modulates the function of different immune cells and determines the outcome of inflammation. Approximately one trillion platelets circulate in the blood of a healthy adult, a quantity that outnumbers by tenfold all other leukocytes in the vasculature. These small non-nucleated cells circulate through the vascular system reaching all organs in the body. Despite being well-known for their roles in coagulation and homeostasis, the contribution of platelets to host defense and the development of autoinflammatory diseases is not fully known. Our group aims to decipher platelets' contributions to host resistance to bacterial and virus infection and sterile inflammation.

Project-related publications

Platelets Fuel the Inflammasome Activation of Innate Immune Cells

Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS.

Cell Rep. 2020 May 12;31(6):107615. doi: 10.1016/j.celrep.2020.107615.

Regulation of Innate Immune Responses by Platelets

Ribeiro LS, Migliari Branco L, Franklin BS.

Front Immunol. 2019 Jun 11;10:1320. doi: 10.3389/fimmu.2019.01320. eCollection 2019.

The Interface Between Inflammatory Mediators and MicroRNAs in Plasmodium vivax Severe Thrombocytopenia

Santos, M.L.S., Coimbra, R.S., Sousa, T.N., Guimaraes, L.F.F., Gomes, M.S., Amaral, L.R., Pereira, D.B., Fontes, C.J.F., Hawwari, I., Franklin, B.S., Carvalho L.H.

Platelets supply p38 MAPK signaling that licenses pro-inflammatory cytokine responses of human monocytes

Ibrahim Hawwari, Nathalia Sofia Rosero Reyes, Lucas S. Ribeiro, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Bernardo S. Franklin

Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis

Begüm Kocatürk, Youngho Lee, Nobuyuki Nosaka, Masanori Abe, Daisy Martinon, Malcolm E Lane, Debbie Moreira, Shuang Chen, Michael C Fishbein, Rebecca A Porritt, Bernardo S Franklin, Magali Noval Rivas, Moshe Arditi

Project-related funding

ERC starting grant

European Research Council

Project-related scientists

Bernardo Franklin Lab
Bernardo Franklin Lab
Bernardo Franklin Lab
Bernardo Franklin Lab

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