Targeting Inflammasomes

Project details

Our previous studies have discovered that inflammasomes have extracellular functions that outlive immune cells and propagate inflammation. We are now focusing on strategies to intervene with extracellular inflammasomes to prevent their deleterious effects in chronic inflammatory diseases.

Project-related publications

The intra- and extracellular functions of ASC specks

Franklin BS, Latz E, Schmidt FI.

Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.