Felix Meissner Laboratory

Mass Spectrometry-based Proteomics

A powerful technology to study immune signaling.

Project details

Our research focusses on proteins, which serve as major signaling molecules, key drug targets and important biomolecules for personalized medicine.

We develop and employ a diverse spectrum of mass spectrometry (MS)-based shotgun proteomics methods to quantitatively characterize distinct layers of immune signaling. If possible, we device streamlined and automated methods compatible with low amounts of primary cellular starting material.

We operate latest generation Orbitrap and TimsTOF mass spectrometers as well as EASY nano-LC and Evosep liquid chromatography systems to achieve high sensitivity, throughput and robustness.

Project-related publications

Quantitative shotgun proteomics: considerations for a high-quality workflow in immunology

Meissner F, Mann M.

Nat Immunol. 2014 Feb;15(2):112-7. doi: 10.1038/ni.2781.

Dissecting intercellular signaling with mass spectrometry-based proteomics

Swietlik JJ, Sinha A, Meissner F.

Curr Opin Cell Biol. 2020 Apr;63:20-30. doi: 10.1016/j.ceb.2019.12.002. Epub 2020 Jan 9.

The Emerging Role of Mass Spectrometry-based Proteomics in Drug Discovery

Meissner F, Geddes-McAlister J, Mann M, Bantscheff M

Nature Reviews Drug Discovery in press

Project-related funding

BMBF CTAP

BMBF

Boehringer Ingelheim Fonds

Boehringer Ingelheim Fonds

SFB 1335

Deutsche Forschungsgemeinschaft (DFG)

SFB 1454

Deutsche Forschungsgemeinschaft (DFG)

SFB 914

Deutsche Forschungsgemeinschaft (DFG)

SFB TRR 274

Deutsche Forschungsgemeinschaft (DFG)

Excellence Cluster ImmunoSensation2

Deutsche Forschungsgemeinschaft (DFG)

Project-related scientists

Felix Meissner Lab
Felix Meissner Lab
Felix Meissner Lab
Felix Meissner Lab
Felix Meissner Lab
Felix Meissner Lab
Felix Meissner Lab

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