Team member CV

Mario Lauterbach, PhD


Eicke Latz Lab

Bio Summary

Obtained his B.Sc in Molecular Biomedicine in Bonn. Got keen on how metabolism and immunity sense and shape each other during his M.Sc. in Life and Medical Sciences. Performed his Master Thesis in Christoph Thiele’s Lab at the University of Bonn studying how macrophages affect adipocyte metabolism. Completed his Ph.D. in Eicke Latz’ lab on the role of macrophage metabolism in shaping epigenetics and the transcriptional response to LPS. Furthermore has been working on western diet and lipid metabolism and their links to macrophage biology.


Passionate cook and cyclist


Lauterbach, M.A., Saavedra, V., Mangan, M.S.J., Penno, A., Thiele, C., Latz, E., and Kuerschner, L. (2020). 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation. Autophagy 24, 1–15.

Lauterbach, M.A., Latz, E., and Christ, A. (2020). Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr−/− Mice. Metabolites 10, 336–20.

Lauterbach, M.A., Hanke, J.E., Serefidou, M., Mangan, M.S.J., Kolbe, C.-C., Hess, T., Rothe, M., Kaiser, R., Hoss, F., Gehlen, J., et al. (2019). Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Immunity 51, 997–1011.e997.

Lauterbach M.A., Wunderlich FT. Macrophage function in obesity-induced inflammation and insulin resistance. Pflugers Arch. 2017;469(3-4):385‐396.

Lauterbach, M.A., Labzin, L.I. and Latz, E. (2017). Inflammation in Atherosclerosis. In: Inflammation (eds J.‐M. Cavaillon and M. Singer). doi:10.1002/9783527692156.ch49

Braga TT, Davanso MR, Mendes D, de Souza TA, de Brito AF, Cruz MC, Hiyane MI, de Lima DS, Nunes V, de Fátima Giarola J, Souto DEP, Próchnicki T, Lauterbach M, Biscaia SMP, de Freitas RA, Curi R, Pontillo A, Latz E, Camara NOS. Sensing soluble uric acid by Naip1-Nlrp3 platform. Cell Death Dis. 2021 Feb 5;12(2):158. doi: 10.1038/s41419-021-03445-w

Davanso MR, Crisma AR, Braga TT, Masi LN, do Amaral CL, Leal VNC, de Lima DS, Patente TA, Barbuto JA, Corrêa-Giannella ML, Lauterbach M, Kolbe CC, Latz E, Camara NOS, Pontillo A, Curi R. Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid. Clin Sci (Lond). 2021 Jan 15;135(1):19-34. doi: 10.1042/CS20201348. PMID: 33399849.

Christ, A., Lauterbach, M., and Latz, E. (2019). Western Diet and the Immune System: An Inflammatory Connection. Immunity 51, 794–811.

Dowling, J.K., Tate, M.D., Rosli, S., Bourke, N.M., Bitto, N., Lauterbach, M.A., Cheung, S., Ve, T., Kobe, B., Golenbock, D., et al. (2019). The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses. J. Immunol. 202, 2384–2396.

Christ, A., Günther, P., Lauterbach, M.A.R., Duewell, P., Biswas, D., Pelka, K., Scholz, C.J., Oosting, M., Haendler, K., Baßler, K., et al. (2018). Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell 172, 162–168.e14.

Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, et al. (2014) Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity 47, 1051–1066.e12.

Alecu, I., Tedeschi, A., Behler, N., Wunderling, K., Lamberz, C., Lauterbach, M.A.R., Gaebler, A., Ernst, D., Van Veldhoven, P.P., Al-Amoudi, A., et al. (2017). Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J. Lipid Res. 58, 42–59.

Labzin, L.I., Lauterbach, M.A.R., and Latz, E. (2016). Interferons and inflammasomes: Cooperation and counterregulation in disease. The Journal of Allergy and Clinical Immunology 138, 37–46.

Palsson-McDermott, E.M., Curtis, A.M., Goel, G., Lauterbach, M.A.R., Sheedy, F.J., Gleeson, L.E., van den Bosch, M.W.M., Quinn, S.R., Domingo-Fernandez, R., Johnston, D.G.W., et al. (2015). Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. Cell Metabolism 21, 65–80.