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Bernardo Franklin Laboratory
Platelets supply p38 MAPK signaling that licenses pro-inflammatory cytokine responses of human monocytes
Ibrahim Hawwari, Nathalia Sofia Rosero Reyes, Lucas S. Ribeiro, Agnieszka Demczuk, Lino L Teichmann, Lisa Meffert, Damien Bertheloot, Bernardo S. Franklin10.1101/2022.08.10.503291
- Platelets are essential to monocyte pro-inflammatory TLR and NLR responses.
- Platelet depletion causes a dynamic and reversible transcriptional reprogramming of human monocytes;
- Platelet supplementation reverts monocyte immunoparalysis in immune thrombocytopenia;
- Platelets supply p38 MAPK signalling that licenses full cytokine responses of human monocytes.