III Publications

Publications of the Institute of Innate Immunity

Back to all publications
Bernardo Franklin Laboratory

Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo

Bertheloot D, Wanderley CWS, Schneider AH, Schiffelers LDJ, Wuerth JD, Tödtmann JMP, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS.

EMBO Mol Med (2022)14:e15415. DOI: 10.15252/emmm.202115415

Inflammasomes are multiprotein complexes that signal by oligomerizing the apoptosis speck-like protein with caspase recruitment and activator domain (ASC) and are involved in multiple inflammatory, metabolic and degenerative diseases. Pharmacological targeting of specific inflammasomes with small molecules is leading to the development of novel drugs for most common diseases. The targeting of ASC oligomers will result in a pan-inflammasome treatment. In their study, Bertheloot et al (2022) developed specific anti-ASC nanobodies and showed their efficacy to disaggregate already formed ASC oligomers and to treat inflammatory diseases in animal models. This approach represents a novel biologic-based treatment for inflammasomes-initiated inflammatory diseases.

Adriouch S and Pelegrin P, EMBO Mol Med (2022)14:e16087 (https://doi.org/10.15252/emmm.202216087)