Eicke Latz Lab Publications

ScienceTeamPublications

Publication metrics Eicke Latz
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Total citations: > 82072
H-Index: 111

Selected publications

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz E.

PLoS Biol. 2022 Nov 7;20(11):e3001351

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

Shan D, Johnson JM, Fernandes SC, Suib H, Hwang S, Wuelfing D, Mendes M, Holdridge M, Burke EM, Beauregard K, Zhang Y, Cleary M, Xu S, Yao X, Patel PP, Plavina T, Wilson DH, Chang L, Kaiser KM, Nattermann J, Schmidt SV, Latz E, Hrusovsky K, Mattoon D, Ball AJ.

Nat Commun. 2021 Mar 26;12(1):1931. doi: 10.1038/s41467-021-22072-9.

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K

Clin Transl Allergy . 2021 Jul 22;11(5):e12045. doi: 10.1002/clt2.12045. eCollection 2021 Jul

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E.

Immunity. 2019 Dec 17;51(6):997-1011.e7. doi: 10.1016/j.immuni.2019.11.009.

Alternative splicing regulates stochastic NLRP3 activity

Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E.

Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1.

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E.

Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E.

J Exp Med. 2017 Jun 5;214(6):1725-1736. doi: 10.1084/jem.20160933. Epub 2017 May 2.

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E.

Sci Transl Med. 2016 Apr 6;8(333):333ra50. doi: 10.1126/scitranslmed.aad6100.

Selected Reviews

Defining trained immunity and its role in health and disease

Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E.

Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4.

Western Diet and the Immune System: An Inflammatory Connection

Christ A, Lauterbach M, Latz E.

Immunity. 2019 Nov 19;51(5):794-811. doi: 10.1016/j.immuni.2019.09.020.

The Western lifestyle has lasting effects on metaflammation

Christ A, Latz E.

Nat Rev Immunol. 2019 May;19(5):267-268. doi: 10.1038/s41577-019-0156-1.

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Aug;17(8):588-606. doi: 10.1038/nrd.2018.97. Epub 2018 Jul 20.

Inflammasome signalling in brain function and neurodegenerative disease

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2018 Oct;19(10):610-621. doi: 10.1038/s41583-018-0055-7.

Innate Immunity and Neurodegeneration

Labzin LI, Heneka MT, Latz E.

Annu Rev Med. 2018 Jan 29;69:437-449. doi: 10.1146/annurev-med-050715-104343. Epub 2017 Nov 6.

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Sep;17(9):688. doi: 10.1038/nrd.2018.149. Epub 2018 Aug 17.

A guiding map for inflammation

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

Próchnicki T, Latz E.

Cell Metab. 2017 Jul 5;26(1):71-93. doi: 10.1016/j.cmet.2017.06.018.

Trained immunity: A program of innate immune memory in health and disease

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ.

Science. 2016 Apr 22;352(6284):aaf1098. doi: 10.1126/science.aaf1098. Epub 2016 Apr 21.

All publications

Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation

Brosseron F, Kleemann K, Kolbe CC, Santarelli F, Castro-Gomez S, Tacik P, Latz E, Jessen F, Heneka MT.

J Neurochem. 2020 Sep 7. doi: 10.1111/jnc.15175. Online ahead of print.

Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr(-/-) Mice

Lauterbach MA, Latz E, Christ A.

Metabolites. 2020 Aug 19;10(9):336. doi: 10.3390/metabo10090336.

NLRP3 inflammasome activation drives tau pathology

Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT.

Nature. 2019 Nov;575(7784):669-673. doi: 10.1038/s41586-019-1769-z. Epub 2019 Nov 20.

Western Diet and the Immune System: An Inflammatory Connection

Christ A, Lauterbach M, Latz E.

Immunity. 2019 Nov 19;51(5):794-811. doi: 10.1016/j.immuni.2019.09.020.

CD82 controls CpG-dependent TLR9 signaling

Khan NS, Lukason DP, Feliu M, Ward RA, Lord AK, Reedy JL, Ramirez-Ortiz ZG, Tam JM, Kasperkovitz PV, Negoro PE, Vyas TD, Xu S, Brinkmann MM, Acharaya M, Artavanis-Tsakonas K, Frickel EM, Becker CE, Dagher Z, Kim YM, Latz E, Ploegh HL, Mansour MK, Miranti CK, Levitz SM, Vyas JM.

FASEB J. 2019 Nov;33(11):12500-12514. doi: 10.1096/fj.201901547R. Epub 2019 Aug 13.

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

Lauterbach MA, Hanke JE, Serefidou M, Mangan MSJ, Kolbe CC, Hess T, Rothe M, Kaiser R, Hoss F, Gehlen J, Engels G, Kreutzenbeck M, Schmidt SV, Christ A, Imhof A, Hiller K, Latz E.

Immunity. 2019 Dec 17;51(6):997-1011.e7. doi: 10.1016/j.immuni.2019.11.009.

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D, Heneka MT.

EMBO J. 2019 Sep 2;38(17):e101064. doi: 10.15252/embj.2018101064. Epub 2019 Jul 30.

Alternative splicing regulates stochastic NLRP3 activity

Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E.

Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1.

The Western lifestyle has lasting effects on metaflammation

Christ A, Latz E.

Nat Rev Immunol. 2019 May;19(5):267-268. doi: 10.1038/s41577-019-0156-1.

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A.

Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252.

AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice

Hupa KJ, Stein K, Schneider R, Lysson M, Schneiker B, Hornung V, Latz E, Iwakura Y, Kalff JC, Wehner S.

Sci Rep. 2019 Jul 22;9(1):10602. doi: 10.1038/s41598-019-46968-1.

Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis

Alvarez-Silva C, Schierwagen R, Pohlmann A, Magdaleno F, Uschner FE, Ryan P, Vehreschild MJGT, Claria J, Latz E, Lelouvier B, Arumugam M, Trebicka J.

Front Immunol. 2019 Feb 8;10:69. doi: 10.3389/fimmu.2019.00069. eCollection 2019.

NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells

Li T, Zehner M, He J, Próchnicki T, Horvath G, Latz E, Burgdorf S, Takeoka S.

Int J Nanomedicine. 2019 May 13;14:3503-3516. doi: 10.2147/IJN.S202379. eCollection 2019.

Circulating microbiome in blood of different circulatory compartments

Schierwagen R, Alvarez-Silva C, Madsen MSA, Kolbe CC, Meyer C, Thomas D, Uschner FE, Magdaleno F, Jansen C, Pohlmann A, Praktiknjo M, Hischebeth GT, Molitor E, Latz E, Lelouvier B, Trebicka J, Arumugam M.

Gut. 2019 Mar;68(3):578-580. doi: 10.1136/gutjnl-2018-316227. Epub 2018 Mar 26.

High-Density Lipoproteins Decrease Proinflammatory Activity and Modulate the Innate Immune Response

Taborda NA, Blanquiceth Y, Urcuqui-Inchima S, Latz E, Hernandez JC.

J Interferon Cytokine Res. 2019 Dec;39(12):760-770. doi: 10.1089/jir.2019.0029. Epub 2019 Jul 23.

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2019 Mar;20(3):187. doi: 10.1038/s41583-019-0137-1.

Membrane fusogenic lysine type lipid assemblies possess enhanced NLRP3 inflammasome activation potency

He J, Li T, Próchnicki T, Horvath G, Latz E, Takeoka S.

Biochem Biophys Rep. 2019 Apr 12;18:100623. doi: 10.1016/j.bbrep.2019.100623. eCollection 2019 Jul.

Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells

Wang L, Schmidt S, Larsen PP, Meyer JH, Roush WR, Latz E, Holz FG, Krohne TU.

J Mol Med (Berl). 2019 Apr;97(4):523-532. doi: 10.1007/s00109-019-01753-5. Epub 2019 Feb 10.

Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic

Aftabizadeh M, Tatarek-Nossol M, Andreetto E, El Bounkari O, Kipp M, Beyer C, Latz E, Bernhagen J, Kapurniotu A.

ACS Chem Neurosci. 2019 Aug 21;10(8):3703-3717. doi: 10.1021/acschemneuro.9b00260. Epub 2019 Jul 25.

Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model

Civit L, Theodorou I, Frey F, Weber H, Lingnau A, Gröber C, Blank M, Dambrune C, Stunden J, Beyer M, Schultze J, Latz E, Ducongé F, Kubbutat MHG, Mayer G.

Sci Rep. 2019 Mar 21;9(1):4976. doi: 10.1038/s41598-019-41460-2.

Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1β Inflammation in Human Macrophages

Rodríguez-Alcázar JF, Ataide MA, Engels G, Schmitt-Mabmunyo C, Garbi N, Kastenmüller W, Latz E, Franklin BS.

J Immunol. 2019 Jan 15;202(2):550-558. doi: 10.4049/jimmunol.1800107. Epub 2018 Dec 17.

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Aug;17(8):588-606. doi: 10.1038/nrd.2018.97. Epub 2018 Jul 20.

Inflammasome signalling in brain function and neurodegenerative disease

Heneka MT, McManus RM, Latz E.

Nat Rev Neurosci. 2018 Oct;19(10):610-621. doi: 10.1038/s41583-018-0055-7.

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe A, Hoss F, Latz E.

Circ Res. 2018 Jun 8;122(12):1722-1740. doi: 10.1161/CIRCRESAHA.118.311362.

Innate Immunity and Neurodegeneration

Labzin LI, Heneka MT, Latz E.

Annu Rev Med. 2018 Jan 29;69:437-449. doi: 10.1146/annurev-med-050715-104343. Epub 2017 Nov 6.

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.

NLRP3 inflammasome activation in inflammaging

Latz E, Duewell P.

Semin Immunol. 2018 Dec;40:61-73. doi: 10.1016/j.smim.2018.09.001. Epub 2018 Sep 26.

Immortalization of Murine Bone Marrow-Derived Macrophages

De Nardo D, Kalvakolanu DV, Latz E.

Methods Mol Biol. 2018;1784:35-49. doi: 10.1007/978-1-4939-7837-3_4.

The intra- and extracellular functions of ASC specks

Franklin BS, Latz E, Schmidt FI.

Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611.

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E.

Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011.

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E.

Nat Rev Drug Discov. 2018 Sep;17(9):688. doi: 10.1038/nrd.2018.149. Epub 2018 Aug 17.

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling

De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL.

J Biol Chem. 2018 Sep 28;293(39):15195-15207. doi: 10.1074/jbc.RA118.003314. Epub 2018 Aug 3.

ASC specks: a biomarker for myelodysplastic syndromes?

Wolf D, Latz E.

Lancet Haematol. 2018 Sep;5(9):e379-e380. doi: 10.1016/S2352-3026(18)30113-3. Epub 2018 Jul 30.

Inhibitory effects of colchicine on inflammasomes

Hoss F, Latz E.

Atherosclerosis. 2018 Jun;273:153-154. doi: 10.1016/j.atherosclerosis.2018.02.026. Epub 2018 Mar 2.

TAK1ng control: TAK1 restrains NLRP3 activation

Mangan MS, Latz E.

J Exp Med. 2018 Apr 2;215(4):1007-1008. doi: 10.1084/jem.20180282. Epub 2018 Mar 5.

Generation of Innate Immune Reporter Cells Using Retroviral Transduction

Cardona Gloria Y, Latz E, De Nardo D.

Methods Mol Biol. 2018;1714:97-117. doi: 10.1007/978-1-4939-7519-8_7.

Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice

Tzeng TC, Hasegawa Y, Iguchi R, Cheung A, Caffrey DR, Thatcher EJ, Mao W, Germain G, Tamburro ND, Okabe S, Heneka MT, Latz E, Futai K, Golenbock DT.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9002-9007. doi: 10.1073/pnas.1801802115. Epub 2018 Aug 20.

PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy

Rolfes V, Idel C, Pries R, Plötze-Martin K, Habermann J, Gemoll T, Bohnet S, Latz E, Ribbat-Idel J, Franklin BS, Wollenberg B.

Oncotarget. 2018 Jun 8;9(44):27460-27470. doi: 10.18632/oncotarget.25446. eCollection 2018 Jun 8.

Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity

Köppert S, Büscher A, Babler A, Ghallab A, Buhl EM, Latz E, Hengstler JG, Smith ER, Jahnen-Dechent W.

Front Immunol. 2018 Sep 4;9:1991. doi: 10.3389/fimmu.2018.01991. eCollection 2018.

Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients

Ahmad F, Mishra N, Ahrenstorf G, Franklin BS, Latz E, Schmidt RE, Bossaller L.

AIDS. 2018 Jan 28;32(3):299-307. doi: 10.1097/QAD.0000000000001693.

Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality

Jansen C, Möller P, Meyer C, Kolbe CC, Bogs C, Pohlmann A, Schierwagen R, Praktiknjo M, Abdullah Z, Lehmann J, Thomas D, Strassburg CP, Latz E, Mueller S, Rössle M, Trebicka J.

Hepatology. 2018 Apr;67(4):1472-1484. doi: 10.1002/hep.29612. Epub 2018 Feb 20.

Systematic evaluation of cell-SELEX enriched aptamers binding to breast cancer cells

Civit L, Taghdisi SM, Jonczyk A, Haßel SK, Gröber C, Blank M, Stunden HJ, Beyer M, Schultze J, Latz E, Mayer G.

Biochimie. 2018 Feb;145:53-62. doi: 10.1016/j.biochi.2017.10.007. Epub 2017 Oct 18.

DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways

Porat A, Giat E, Kowal C, He M, Son M, Latz E, Ben-Zvi I, Al-Abed Y, Diamond B.

Front Immunol. 2018 Dec 11;9:2824. doi: 10.3389/fimmu.2018.02824. eCollection 2018.

Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes

Steinhagen F, Zillinger T, Peukert K, Fox M, Thudium M, Barchet W, Putensen C, Klinman D, Latz E, Bode C.

Eur J Immunol. 2018 Apr;48(4):605-611. doi: 10.1002/eji.201747338. Epub 2017 Dec 27.

RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo

Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Haßel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Gröber C, Händler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Förster I.

Mol Ther. 2018 Jan 3;26(1):95-104. doi: 10.1016/j.ymthe.2017.10.005. Epub 2017 Oct 13.

Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells

Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukai T, Kaneko T, Miyazaki T, Latz E, Hara Y.

J Periodontal Res. 2018 Jun;53(3):353-361. doi: 10.1111/jre.12520. Epub 2017 Nov 20.

Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids

Li T, He J, Horvath G, Próchnicki T, Latz E, Takeoka S.

Nanomedicine. 2018 Feb;14(2):279-288. doi: 10.1016/j.nano.2017.10.011. Epub 2017 Nov 8.

A guiding map for inflammation

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT.

Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

Próchnicki T, Latz E.

Cell Metab. 2017 Jul 5;26(1):71-93. doi: 10.1016/j.cmet.2017.06.018.

Institute of Innate Immunity
University Hospital Bonn
Biomedical Center (BMZ 2)
Building 12
2G
Venusberg-Campus 1
53127 Bonn, Germany

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